What is Amyloidosis?
Amyloidosis is a rare disease that occurs when amyloid proteins are deposited in tissues and organs. Amyloid proteins are abnormal proteins that the body cannot break down and recycle, as it does with normal proteins. When amyloid proteins clump together, they form amyloid deposits. The buildup of these deposits damages a person’s organs and tissues. There is no treatment for amyloidosis, but ayurvedic treatment of amyloidosis is effective for some extent. Ayurvedic treatment of amyloidosis along with yoga and breathing exercises can cure amyloidosis.
Amyloidosis can affect different organs and tissues in different people and can affect more than one organ at the same time. Amyloidosis most frequently affects the kidneys, heart, nervous system, liver, and digestive tract. The symptoms and severity of amyloidosis depend on the organs and tissues affected.
Types of Amyloidosis-
Two types of amyloidosis
1. Primary amyloidosis — unknown Causes
2. Dialysis-related amyloidosis— Dialysis-related amyloidosis happens to people who have kidney failure and have been on dialysis for a long time.
Amyloidosis Sign and Symptoms –
The most common sign of primary amyloidosis is nephrotic syndrome, which is a group of symptoms that includes:
- albuminuria—an increased amount of albumin, a protein, in the urine.
- hyperlipidemia—a condition in which a person’s blood has more-than-normal amounts of fats and cholesterol.
- edema—swelling, typically in a person’s legs, feet, or ankles and less often in the hands or face.
- hypoalbuminemia—a condition in which a person’s blood has less-than-normal amounts of albumin
- shortness of breath
- low blood pressure
- numbness, tingling, or a burning sensation in the hands or feet
- weight loss
The most common symptoms of dialysis-related amyloidosis are:
- Dialysis-related amyloidosis most often affects bones, joints, and the tissues that connect muscle to bone, called tendons. The disease may also affect the digestive tract and organs such as the heart and lungs.
- Joint pain and stiffness
- Swelling of ankles joints and legs
- Cysts (fluid-filled sacs) in bones which lead to bone fractures.
- Numbness or tingling in hands and fingers.
- Purpura around the eyes.
- Enlarged tongue.
- Severe fatigue and weakness.
- Shortness of breath with minimal exertion.
- Unable to lie flat in bed due to shortness of breath.
- Diarrhea, possibly with blood, or constipation.
- Unintentional weight loss of more than 10 pounds (4.5 kilograms).
- Skin changes, such as thickening or easy bruising, and purplish patches around the eyes.
- An irregular heartbeat.
- Difficulty swallowing.
Risk factors of Amyloidosis
Factors that increase your risk of amyloidosis include:
- Age. Most people diagnosed with amyloidosis are between ages 60 and 70, although earlier onset occurs.
- Sex. Amyloidosis occurs more commonly in men.
- Other diseases. Having a chronic infectious or inflammatory disease increases your risk of amyloidosis.
- Family history. Some types of amyloidosis are hereditary.
- Kidney dialysis. Dialysis can’t always remove large proteins from the blood. If you’re on dialysis, abnormal proteins can build up in your blood and eventually be deposited in tissue. This condition is less common with more modern dialysis techniques.
- Race. People of African descent appear to be at higher risk of carrying a genetic mutation associated with a type of amyloidosis that can harm the heart.
Complications of amyloidosis-
The potential complications of amyloidosis depends on which organs the amyloid deposits–
Heart –Amyloid reduces heart’s ability to fill with blood between heartbeats. Less blood is pumped with each beat, and you may experience shortness of breath. If amyloidosis affects your heart’s electrical system, your heart rhythm may be disturbed. Amyloid-related heart problems can become life-threatening.
Kidneys— Amyloid can harm the kidneys’ filtering system, causing protein to leak from blood into urine which may lead to kidney failure and the need for dialysis.
Nervous system — Pain, numbness or tingling of your fingers or numbness, lack of feeling or a burning sensation in your toes or the soles of your feet. If amyloid affects the nerves that control your bowel function, you may experience periods of alternating constipation and diarrhea. If it affects the nerves that control blood pressure, you may feel faint after standing up too quickly.
Diagnosis of amyloidosis-
- T3, T4, TSH
- Lipid Profile
- Urine C/E
- Biopsy- A tissue sample may be taken and checked for signs of amyloidosis. The biopsy may be taken from the fat under the skin on your abdomen (fat aspirate), bone marrow, or an affected organ — such as your liver or kidney.
- Imaging tests
Treatment of Renal amyloidosis-
There’s no cure for amyloidosis. But treatment can help manage signs and symptoms and limit further production of amyloid protein. If the amyloidosis has been triggered by another condition, such as rheumatoid arthritis or tuberculosis, treating the underlying condition can be helpful.
Medications for amyloidosis
Chemotherapy— cancer medicines are used in amyloidosis to stop the growth of abnormal cells that produce the protein leading to formation of amyloid.
Heart medications— In case of heart involvement anti-coagulant and heart medicines are given to reduce the risk of clots and arrhythmia.
Organ transplant— Your doctor might suggest surgery to replace your heart or kidneys if amyloid deposits have severely damaged those organs. Some types of amyloid are formed in the liver, so a liver transplant could halt that production
Dialysis–related amyloidosis has no cure; however, a successful kidney transplant may stop the disease from progressing.
Diet and Life-Style Changes for Amyloidosis-
Researchers have not found that eating, diet, and nutrition play a role in causing or preventing primary amyloidosis of the kidneys or dialysis-related amyloidosis. People with nephrotic syndrome may make dietary changes such as limiting dietary sodium often from salt, to help reduce edema and lower blood pressure decreasing liquid intake to help reduce edema and lower blood pressure.
Eat a diet low in saturated fat and cholesterol to control excess fats and cholesterol in the blood
Health care providers may recommend that people with kidney disease eat moderate or reduced amounts of protein. Proteins break down into waste products that the kidneys filter from the blood. Eating more protein than the body needs may burden the kidneys and cause kidney function to decline faster. However, protein intake that is too low may lead to malnutrition, a condition that occurs when the body does not get enough nutrients.
Natural Treatment of Renal Amyloidosis-
There are ways to ease your symptoms and improve your well-being with natural and complementary therapies as-
Do regular light exercises like Walking, Jogging, stretching, Running or anything that helps keep you moving without being too strenuous. By exercising regularly, you can help fight pain and fatigue related to amyloidosis.
2. Sleep therapy–
Daytime fatigue can make it difficult to sleep at night, especially if you take a lot of naps. Then, insomnia can make fatigue during the day worse. This is a vicious cycle that can be made worse by pain and discomfort in the middle of the night.
Do Meditation and deep breathing exercises for sound sleep.
3. Reduced-salt diet–
With amyloidosis,kidneys may not retain protein efficiently and heart’s ability to pump blood may also be impaired. Together, this can cause swelling, especially in lower extremities like the legs and feet. Too much salt can exacerbate such issues. Reducing the amount of salt in your diet can reduce swelling in the body.
4. Meal replacements-
People living with amyloidosis often don’t receive adequate nutrients from food. This may be due to tongue swelling, difficulty swallowing, loss of appetite, or intestinal dysfunction So, take Tasty, digestive, easily swallow able balanced diet. Like fresh seasonal fruits and vegetables, foods rich in fibers e.g.-bananas, pineapples, papayas, oranges, spinach, tomatoes, and sweet potatoes, are all great additions to your diet.
Foods rich in omega3 fatty acids are beneficial. Avoid excessive intake of coffee, alcohol, junk foods and spices. This way, you can get the nutrients for the body to maintain Vital functions.
5. Fluid adjustments
Don’t take excessive fluid. This helps to reduced symptoms of leg swelling and shortness of breath.
6. Foot massage
It can increase blood flow to alleviate your symptoms. Foot massage at bed time helps in sound sleep.
7. Eat less at a time and avoid taking 2 to 3 heavy meals in a day. One can have cauliflower, ash gourd, radish, bottle gourd, bell peppers, apples, papaya, pears, etc. Limit the intake of dried beans, mushroom, potatoes, spinach, mushrooms, apricots, etc.
Limit the intake of all dairy products.Avoid or limit the intake of protein and potassium-rich fruits and other foods, so exclude all citrus fruits.
Coconut water and aloe vera are good to have to detoxify the body.Basil or Talsi is good to have to enhance immune system. Chew fresh leaves of basil every morning on an empty stomach.
Say no to smoking and chewing tobacco.
Even if you take medications or undergo other treatments for amyloidosis, complementary therapies can help. When used in conjunction with conventional medicine, these therapies can make it easier to deal with your symptoms and medication side effects.
Herbs for Renal Amyloidosis-
Ayurveda explains many herbal treatments for kidney failure. Although there is no satisfactory treatment in allopathic science other than dialysis and kidney transplant, Ayurveda has a lot of herbs for kidney failure which work quite well eg-
Punarnava (Boerhavia diffusa)
Punarnava helps to maintains fluids level in the cells and aid to healthy flow of urine. Due to its anti-inflammatory properties, Punarnava reduces swelling in the feet and joints Regular use of this ayurvedic herbs treats kidney failure and revitalizes the whole body.
Kaasni (Cichorium intybus)
Kaasni is the best remedy for all kinds of kidney disorders. It is highly beneficial in respiratory problems. Kaasni works best for kidney failure complications caused due to respiratory system. It acts as an anti-inflammatory.
Varun treats kidney failure from its root. It fights against kidney stones by decreasing the body’s construction of oxalate and deactivating the glycolate oxidase enzyme. It provides strength to the urinary tract and prostate function. This herb is effective in treatment of chronic migraines, kidney stones, intestinal worms, intestinal bleeding, renal calculi and more.
Gokshur (Tribulus terrestris)
This ayurvedic herb treats urinary problems caused by renal infection, urinary discharge and kidney failure. It enhances a person’s immunity power and capability to fight against foreign bodies effectively.
Palaash (Butea monosperma)
This is the best Ayurvedic herb for the functioning of kidneys and eradicates symptoms of kidney failure.
It boots liver and kidney functions. It acts as an antiseptic and helps one to get rid of intestinal infections, worm infestations, intestinal parasites, etc. Thus, it is beneficial in eradicating symptoms of kidney failure. It efficiently controls diabetes by reducing blood sugar. It is a great remedy for bones and fractures.
Ayurvedic Medicines for amyloidosis–
Ayurvedic medicines which can be helpful in amyloidosis are
Ras raj ras
Varihad Vat chintamaniras
Yoga asana For Renal Amyloidosis-
Yoga along with Breathing exercises keeps the mind and body in sound state. It normalizes the body hormones and balances the tridosha (Vata,Pitta,Kapha). Yoga keeps the internal organs healthy, balances the various systems in the body, and effectively controls the stress of the body and mind. It detoxifies the body and cleansing the internal organs. This also ensures that blood flows to various parts of the body, keeping it fresh and energetic. Yoga poses stimulate and massage various organs that help bring the body to an optimal condition.
Start with these simple yoga poses to ensure the health of your kidneys. These poses affect other parts of the body as well. So in your practice of yoga for kidney health, you are helping the entire body. Good health starts here.
Yoga asanas brings a state of relaxation in the body. They helps to maintain water balance in the body. This enables sound sleep schedules and hence better rest. A well-rested body is better able to perform functions such as regulation of water in the body and stabilizing the heartbeat.Some important yoga asana for renal amyloidosis are as-
Paschimottanasana (Two-Legged Forward Bend)
Setu Bandhasana (Bridge Pose)
Naukasana (Boat Pose)
Different poses useful in Renal amyloidosis and kidney diseases are as-